This guide brings together the most advanced information on the problem of sepsis. It includes sections dedicated to modern terminology, diagnostics, and epidemiology of sepsis, with the most important section detailing the principles of therapeutic tactics for this severe condition.

The authors highlight the growing issue of antibiotic resistance among sepsis pathogens and the significance of microbiological diagnostics in selecting rational therapy.

Considering that rational sepsis therapy is unthinkable without effective and safe antimicrobial chemotherapeutic agents, Section 3 outlines the main principles of therapeutic tactics for sepsis. Importantly, the authors provide clear clinical recommendations based on evidence-based medicine principles.

PJSC "Krasfarma," a leading Russian manufacturer of modern, effective, and safe hospital antibiotics from various groups, recognizing the medical and social significance of sepsis as a pressing issue in modern clinical practice, supported the release of this practical guide.

In honoring the high professionalism and expertise of the authors involved in creating the chapters of the book, PJSC "Krasfarma" responsibly presents two antimicrobial drugs with unique properties to the medical community: Fosfomycin powder for the preparation of intravenous solutions and Sabvixine (INN: Polymyxin B) powder for the preparation of injection solutions, aimed at overcoming microbial resistance and optimizing the clinical and microbiological effectiveness of sepsis treatment.

We present Chapter 3.1 of the practical guide, dedicated to the antimicrobial therapy of sepsis.

Chapter 3.1. Antimicrobial Therapy of Sepsis: Main Approaches to Empirical and Targeted Therapy
(Authors: I.N. Petukhova, Z.V. Grigoryevskaya, N.V. Dmitrieva)