Advances in technologies and surgical approaches to the treatment of degenerative joint diseases have contributed to the widespread implementation of joint replacement (arthroplasty) surgeries in clinical practice. It is not surprising that surgical treatment for previously "incurable" pathologies, which lead to disability due to severe pain and immobility, is now being routinely performed.

Perioperative antibiotic prophylaxis (PAP) aims to minimize the frequency of postoperative infectious complications in the surgical area (Surgical Site Infections - SSI), such as wound infection and periprosthetic infection.

The article "Do We Know Everything About Perioperative Antibiotic Prophylaxis in Joint Arthroplasty?" presents the main principles of rational antibiotic use for PAP in hip and knee arthroplasty.